Methyl Indole AM Resin: The Indole-Loaded Resin for Efficient Solid-Phase Synthesis

If you’re looking for a high-performance resin for synthesizing indole-containing compounds, Methyl Indole AM Resin is your go-to solution. Engineered for solid-phase synthesis (SPS), this resin features a preloaded 2-methylindole moiety on an aminomethyl polystyrene (AM) backbone, enabling efficient and targeted construction of indole-based peptides and small molecules.

In this blog, we’ll cover everything you need to know about Methyl Indole AM Resin—from its structure and applications to handling tips and SEO-friendly search terms for procurement.

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What Is Methyl Indole AM Resin?

Methyl Indole AM Resin is a polystyrene-based resin functionalized with 2-methylindole, anchored through an aminomethyl linker. It is specifically designed for solid-phase organic synthesis, especially in the development of indole derivatives, peptidomimetics, and bioactive compounds.

Quick Facts:

• Type: Polystyrene-based resin

• Functional Group: 2-Methylindole

• Linker: Aminomethyl (AM)

• Application: Solid-phase synthesis (SPS)

• Loading Capacity: Typically 0.3–0.9 mmol/g (check with supplier)

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Why Choose Methyl Indole AM Resin?

Preloaded Indole Core

Save time and eliminate variability by starting your synthesis with a high-purity, resin-bound indole scaffold.

Compatible with Fmoc-SPPS

Ideal for Fmoc solid-phase peptide synthesis, enabling construction of indole-containing peptides or hybrid structures.

High Stability and Efficiency

The 2-methyl substitution improves the stability of the indole and reduces side reactions during synthesis.

Suitable for Medicinal Chemistry

Perfect for creating alkaloid-inspired structures, indole-based drugs, and SAR (structure-activity relationship) libraries.

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Top Applications

It is widely used in:

• Indole-based drug discovery

• Peptidomimetic synthesis

• Fragment-based lead generation

• Synthesis of tryptophan analogs

• Combinatorial chemistry and library screening

Because the indole ring is a privileged structure found in many natural products and pharmaceuticals, this resin is a powerful tool for lead optimization and early-stage drug development.

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How to Use Methyl Indole AM Resin

1. Swelling

Pre-swell in DMF, DCM, or NMP for 30–60 minutes before use.

2. Chain Extension

React the free amine via standard amide bond formation or other coupling strategies.

3. Cleavage

Typically cleaved under acidic conditions such as TFA with scavengers (e.g., water, TIS).

4. Work-Up

Simple filtration and solvent evaporation yield the crude product, often ready for minimal purification.

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Storage and Handling Tips

• Store dry at 2–8 °C in an airtight container.

• Protect from moisture and direct light.

• Handle using standard solid-phase synthesis protocols.

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Where to Buy Methyl Indole AM Resin

When purchasing this product search using SEO-friendly terms like:

• Buy Methyl Indole AM Resin

• 2-Methylindole AM resin for SPPS

• Preloaded indole resin

• Indole-functionalized resin for peptide synthesis

Several chemical suppliers and specialty resin manufacturers stock this resin in various mesh sizes and loading capacities. Be sure to request a Certificate of Analysis (CoA) for quality assurance.

Phone : +49 1512 4714765 ( Germany )
Phone : +1 (702) 381-3042 ( USA )
Email : [email protected]
Address : Cunostraße 56, 14193 Berlin. Germany
Address : 7373 Rowlett Park Dr, Tampa, FL 33610, United States.